Current Trials

Current Trials (actively recruiting):

ANNEXA-I – Trial of andexanet in ICH patients receiving an oral FXa inhibitor

CATIS-ICAD (Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in Intracranial Atherosclerotic Disease),

CONVINCE (University College Dublin): Colchicine for Stroke Prevention in Non-cardio Embolic Stroke

CREST-2 (NIH-NINDS): Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

EMPOWER (CIHR): Engaging Persons With Cerebral Venous Thrombosis For Meaningful Outcomes And Peer Support

FRONTIER (NoNo Inc): Field Randomization of NA-1 Therapy in Early Responders

HI-ROLLER (UBC Dept of Neurology):high-Risk Patient Protocol for Left Atrial Appendage Closure

PROPHECY (Boehringer-Ingleheim Canada): Prospective Validation of Predictive Features of Paroxysmal Atrial Fibrillation

SEARCH Study (StrokE and vAscular Risk factors contributing to neuroCognitive decline in adult
congenital Heart disease):

SECRET (Canadian Stroke Consortium): Study of rivaroxaban for Cerebral Venous Thrombosis

Stroke Permission to Contact REGISTRY (Heart and Stroke Foundation): Prospective Recruitment of Stroke Patients at Vancouver General Hospital and the Vancouver Stroke Program

TEMPO-2 (Calgary Stroke Program): A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion


Follow-up only:

REDUCE (GORE Inc): A Randomized Controlled Trial of PFO closure plus antiplatelet versus standard of care for ESUS/TIA

YOUNG ESUS (PCHRI/Bayer AG): Observational Study of Young Patients with Embolic Stroke of Undetermined Source (ESUS)

Upcoming Trials:

ARCADIA – Atrial cardiopathy and antithrombotic drugs in prevention after cryptogenic stroke

AXIOMATIC-SSP – a study on BMS-986177 for the prevention of a stroke in patients receiving aspirin and clopidogrel

EASI-TOC – Endovascular acute stroke intervention – Tandem occlusion trial

RCVS-NIRS – Utility of Near-Infrared Spectroscopy and Transcranial Doppler Ultrasound in Suspected Reversible Cerebral Vasoconstriction Syndrome

Recently completed:

COGNITION IN YOUNG STROKE (Heart and Stroke Foundation): Cognitive Deficits in Young Stroke Patients as Measured by the NIH Toolbox Cognitive Battery, MoCA and Spontaneous Speech

DATAS-II (CIHR): Dabigatran following Transient ischemic attack and minor Stroke

ESCAPE NA-1 (NoNo Inc): A Randomized Controlled Trial of NA-1 for Acute Stroke selected for Endovascular Revascularization

NAVIGATE-ESUS (Bayer): Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

NASPAF ICH (PHRI): A Randomized Controlled Trial of NOACs for Atrial Fibrillation and previous ICH

POINT (NINDS-NETT/UCSF): Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

TEC4Home (VCHRI/UBC & VGH Hospital Foundation): Home Telemonitoring Technology in Managing Hypertension among Stroke/TIA Patients