Publications

PUBLICATIONS IN THE LAST FIVE YEARS FROM THE VANCOUVER STROKE PROGRAM:

Odden MC, McClure LA, Peralta CA, White CL, Pergola PE, Field TS, Benavente OR, Sawaya BP. Achieved Blood Pressure and Outcomes in the Setting of Intensive Systolic Blood Pressure Control: The Secondary Prevention of Small Subcortical Strokes Trial. Hypertension. 2016;67:63-69.

 

Wilson LK, Pearce LA, Anderson DG, Arauz A, Tapia J, Benavente OR, Field TS. Morphological features of pontine infarcts in the SPS3 Trial: Association with baseline risk factors and prognosis. International Journal of Stroke 2016; 11:412-9.

 

Field TS, Doubal FN, Johnson W, Backhouse E, McHutchison C, Cox S, Corley J, Pattie A, Gow AJ, Shenkin S, Cvoro V, Morris Z, Staals J, Bastin M, Deary IJ, Wardlaw JM. Associations between early life characteristics and late life burden of Small Vessel Disease (SVD) score in the Lothian Birth Cohort 1936. Aging 2016;8:2039-61.

 

Field TS, Camden MC, Al-Shimemeri S, Lui G, Lee AYY. Off-label Use of Novel Oral Anticoagulants for Cerebral Venous Thrombosis: A Canadian Survey. International Journal of Stroke 2016. Epub Jan 12. DOI: 10.1177/1747493015616643 [Letter]

 

Field TS, Camden MC, Alshimemeri S, Lui G, Lee AYYL. Antithrombotic strategy in Cerebral Venous Thrombosis – Differences between neurologists and hematologists in a Canadian Survey. Canadian Journal of Neurological Sciences 2017;44:116-9.

 

Funnell C, Doyle-Waters M, Brasher P, Field TS. MRI features of small vessel disease in diabetic versus non-diabetic patients: Protocol for a Systematic Review and Meta-analysis. Systematic Reviews 2017;6(1):7.

 

Smith EE, Cieslak A, Barber P, Chen J, Chen YW, Donnini I, Edwards JD, Elbayoumi H, Frayne R, Field TS, Hegedus J, Hanganu V, Ismail Z, Kanji J, Nakajima M, Noor R, Peca S, Sahlas D, Sharma M, Sposato L, Swartz RH, Zerna C, Black S, Hachinski V. Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment. Journal of the American Heart Association. JAHA 2017;5;6(5). Pii: e005568. DOI 10.1161/JAHA.117.005568.

 

Ng KH, Sharma M, Benavente OR, Gioia LC, Field TS, Hill MD, Coutts SB, Butcher K. Dabigatran following acute TIA and minor stroke: DATASII. Intl J Stroke 2017;12:910-4.

 

Schmitt T, Thronton AE, Rawtaer I, Barr AM, Gicas K, Lang DJ, Vertinsky T, Rauscher A, Procyshyn RM, Buchanan T, Cheng A, McKay S, Leonova O, Langheimer V, Field TS, Heran M, Vila-Rodriguez F, O’Connor TA, MacEwan W, Honer WG, Panenka WJ. Traumatic Brain Injury in a Community-based Cohort of Homeless and Vulnerably-housed Individuals. J Neurotrauma 2017;34:3301-10.

 

Ku E, Scherzer R, Odden MC, Shlipak M, Benavente OR, White CL, Field TS, Pergola P, Peralta CA. Patterns of blood pressure response during intensive hypertension treatment and clinical events. Blood Pressure 2018;27:73-81.

 

Ayling OGS, Alotaibi NM, Wang JZ, Fatehi M, Ibrahim GM, Benavente O, Field TS, Gooderham PA, Macdonald RL. Suboccipital Decompressive Craniectomy for Cerebellar Infarction: A Systematic Review and Meta-Analysis. World Neurosurg 2018;110:450-459.e5.

 

Wein T, Lindsay P, Cote R, Foley N, Berlingieri J, Chogal S, Bourgoing A, Buck B, Cox J, Davidson D, Dowlatshahi D, Douketis J, Falconer J, Field TS, Gioia L, Gubitz G, Haberts J, Jaspers S, Lum C, McNamara Morse D, Pageau P, Rafay M, Rodgerson A, Semchuk B, Sharma M, Shoamanesh A, Tamayo A, Smitko E, Gladstone DJ. “Canadian Stroke Best Practice Recommendations: Secondary Prevention of Stroke, Sixth Edition Practice Guidelines Update, 2017.” Int J Stroke 2018;13:420-43.

 

Beauchemin P, Iorio R, Gilks CB, Traboulsee A, Field TS, Carruthers R. “Paraneoplastic Neuromyelitis Optica: A single-centre description with cases of histological validation. Multiple Sclerosis and Related Disorders. 2017; 20:37-42.

 

Squair JW, Field TS, Phillips AA. Journal club: Relationship between carotid arterial properties and cerebral white matter hyperintensities. Neurology 2018; 90:338-40.

 

Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Padwal RS, Tran KC, Grover S, Rabkin SW, Moe GW, Howlett JG, Lindsay P, Hill MD, Sharma M, Field TS, Wein TH, Shoamanesh A, Dresser GK, Hamet P, Herman RJ, Burgess E, Gryn SE, Grégoire JC, Lewanczuk R, Poirier L, Campbell TS, Feldman RD, Lavoie KL, Tsuyuki RT, Honos G, Prebtani APH, Kline G, Schiffrin EL, Don-Wauchope A, Tobe SW, Gilbert RE, Leiter LA, Jones C, Woo V, Hegele RA, Selby P, Pipe A, McFarlane PA, Oh P, Gupta M, Bacon SL, Kaczorowski J, Trudeau L, Campbell NRC, Hiremath S, Roerecke M, Arcand J, Ruzicka M, Prasad GVR, Vallée M, Edwards C, Sivapalan P, Penner SB, Fournier A, Benoit G, Feber J, Dionne J, Magee LA, Logan AG, Côté AM, Rey E, Firoz T, Kuyper LM, Gabor JY, Townsend RR, Rabi DM, Daskalopoulou SS; Hypertension Canada. Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children. Canadian Journal of Cardiology 2018; 34:506-25.

 

Rebchuk AD, Deptuck HM, O’Neill ZR, Fawcett DS, Silverberg ND, Field TS. Validation of a novel video-conference administration protocol for the NIH Toolbox – Cognition Battery. Telemedicine and e-Health 2019;25:237-42.

 

Funnell C, Heran M, Teal P, Field TS. “Rapidly expanding venous intracerebral hemorrhage with spot sign.” BMJ Case Reports 2018; Mar 23. Pii:bcr-2017-223055.

Parappilly BP, Field TS, Mortenson WB, Sakakibara BM, Eng JJ.  Effectiveness of interventions involving nurses in secondary stroke prevention: A systematic review and meta-analysis. Eur J Cardiovasc Nurs. 2018;17:728-36.

 

Lai J, Harrison RH, Plecash A, Field TS. A review of persistent post-stroke headache- a new entry in the International Classification of Headache Disorders, 3rd edition. Headache 2018;58:1442-53.

 

Menon BK, Najm M, Al-Ajlan F, Puig Alcantara J, Dowlatshahi D, Calleja A, Sohn SI, Ahn SH, Poppe A, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Smith EE, Coutts SB, Barber PA, Bal S, Mishra S, Trivedi A, Dey S, Goyal M, Hill MD, Demchuk AM. IV tPA Recanalization Rates with Intravenous Alteplase for Acute Ischemic Stroke Treatment. JAMA 2018;320(10):1017-1026.

 

Parappilly B, Mortenson B, Field TS, Eng JJ. Exploring perceptions of stroke survivors about secondary prevention: a longitudinal qualitative study. Disability and Rehabilitation 2019;22:1-7.

 

Field TS, Weijs B, Curcio A, Giustozzi M, Saudikas S, Katholing A, Wallenhorst C, Weitz JI, Cohen AT, Martinez CM. Incident atrial fibrillation, dementia, and the role of anticoagulation: A population-based cohort study. Thrombosis and Haemostasis 2019;119:981-991.

 

Yogendrakumar V, Alajan F, Najm M, Puig J, Calleja A, Sohn SI, Ahn S, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Hill MD, Demchuk AM, Menon BK, Dowlatshahi D. Clot Burden and Early Ischemia Predict Intracranial Hemorrhage Following Endovascular Therapy. American Journal of Neuroradiology 2019;40:655-60.

 

Parappilly B, Field TS, Mortenson WB, Sakakibara BM, Eng JJ. Determinants influence the pre-stroke behaviours and cardiovascular disease risk of stroke patients: A cross-sectional study. J Stroke Cerebrovasc Dis 2019;28:1509-18.

 

Smith JMC, Andrade JG, Human D, Field TS. Adults with congenital heart disease: Cerebrovascular considerations for the neurologist. Frontiers in Neurology. 2019; 10:329.

 

Field TS, Hill MD. Cerebral venous thrombosis – We should ask the right questions to get better answers. Stroke 2019;50:1598-1604.

 

Zhou LW, Panenka WJ, Jones AA, Gicas KM, Thornton AE, Heran MKS, Volders D, Lang DJ, Vertinsky AT, Rauscher A, Su W, Barr AM, MacEwan GM, Honer WG, Field TS. Prevalence and  Risk Factors for Brain Infarcts and Associations with Cognitive Performance in Residents of Marginal Housing. JAHA 2019;8;e011412.

 

O’Neill ZR, Deptuck H, Quong LR, King-Azote P, Maclean G, Villaluna K, Field TS. Reasons for refusal: Who says “no” to participation in stroke clinical trials and why. Trials 2019;20:313.

 

Field TS. Recurrent Venous Thromboembolism after Cerebral Venous Thrombosis: Which lower-risk survivors are at risk for recurrence? Thrombosis Research 2019;182:182-3.

 

Kier M, Ebert P, Kovacs AH, Smith JMC, Kwan E, Field TS, Brossard-Racine M, Marelli A. Neurocognition in adult congenital heart disease: How to monitor and prevent progressive decline. Canadian Journal of Cardiology 2019; 35:1675-1685

 

Coutts SB, Hill MD, Moreau F, Goyal M, Camden MC, Asdaghi N, Field TS, Penn A, Swartz R, Boulanger JM, Campbell B, Krause M, Mikulik R, Mandzia J. Rate and prognosis of brain ischemia in low-risk transient neurological events. JAMA Neurology 2019;  76:1439-45.

 

Smith JMC, Field TS. Pain in adults with cerebral palsy: measuring the contribution of spasticity. Developmental Medicine and Child Neurology 2020;62:271.

 

Gensicke H, Evans JW, Al Ajlan FS, Dowlatshahi D, Najm M, Calleja AL, Puig J, Il-Sohn S, Ahn SH, Poppe AY, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Hill MD, Goyal M, Demchuk AM, Menon BK. Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERSSeCT multinational multicenter prospective cohort study. Neuroradiology 2020;62:301-6.

 

Healey JS, Amit G, Field TS. Atrial fibrillation and stroke: How much atrial fibrillation is enough to cause a stroke? Curr Opin Neurol 2020;33:17-33.

 

Kuang H, Qiu W, Najm M, Dowlatshahi D, Mikulik R, Poppe A, Puig J, Castellanos M, Sohn SI, Ahn SH, Calleja A, Jin A, Asil T, Asdaghi N, Field TS, Coutts S, Hill MD, Demchuk AM, Goyal M, Menon BK. Validation of an Automated ASPECTS methods on non-contrast CT scans of acute ischemic stroke patients. International Journal of Stroke 2020;15:528-34.

 

Byrne D, Walsh JP, Schmiedeskamp H, Settecase F, Heran M, Niu B, Salmeen AK, Rohr B, Field TS, Murray M, Rohr A. Prediction of hemorrhage after successful recanalization using dual energy CT parenchymal iodine concentration ratio relative to superior sagittal sinus. AJNR 2020; 41:64-70.

 

Hill MD, Goyal M, Menon B, Noguiera R, McTaggart R, Demchuk A, Poppe A, Buck B, Field TS, Dowlatshahi D, van Adel B, Swartz R, Shah R, Sauvageau E, Zerna C, Ospel J, Joshi M, Almekhalfi M, Ryckborst K, Lowerison M, Heard K, Garman D, Haussen D, Cutting S, Coutts S, Roy D, Rempel J, Rohr A, Iancu D, Sahlas D, Yu AYX, Devlin T, Hanel R, Puetz V, Silver F, Campbell B, Chapot R, Teitelbaum J, Mandzia J, Kleinig T, Tarkel Parella D, Heck D, Kelly M, Bharatha A, Bang OY, Jadhav A, Gupta R, Frei D, Tarpley J, McDougall C, Holmin S, Rha YH, Puri A, Camden MC, Thomalla G, Choe H, Phillips S, Schindler J, Thornton J, Nagel S, Heo JH, Sohn SI, Psychogios MN, Budzik R, Sharkman S, Coleman M, Burns P, Murphy S, Lopez G, English J, Tymianski M. Neuroprotection with nerenitide in acute ischemic stroke due to large vessel occlusion: the ESCAPE NA-1 Trial. Lancet 2020; 395:878-87.

 

Butcher K, Sharma M, Ng K, Sheridan P, Field TS, Coutts SB, Siddiqui M, Gioia L, Buck B, Hill MD, Miller J, Khlar A, Sivakumar L, Benavente OB, Hart RG. Dabigatran therapy in acute non-cardioembolic ischemic stroke patients: a randomized controlled trial. Stroke 2020;51:1190-8.

 

D’Esterre C, Tariq S, Sah RG, McTaggart R, Butcher K, Aviv RI, Swartz R, Field TS, Tarpley J, Shah R, Noguiera R, Hill MD, Demchuk AM, Goyal M, Barber PA. Recanalization following Endovascular treatment and imaging of PErfusion, Regional inFarction and atrophy to Understand Stroke Evolution – NA1 (REPERFUSE-NA1). International Journal of 2020;15:343-9.

 

Wien T, Lindsay MP, Gladstone DG, Poppe A, Bell A, Casaubon LK, Foley N, Coutts S, Cox J, Douketis J, Field TS, Gioia L, Habert J, Lang E, Mehta S, Papoushek C, Semchuk W, Sharma M, Udell J, Lawrence S, Mountain A, Gubitz G, Dowlatshahi D, de Jong A, Simard A, Yip CYY, Smith EE. Canadian Stroke Best Practice Recommendations: The use of acetylsalicylic acid (ASA) for the primary prevention of vascular disease. CMAJ 2020;192:E302-11.

 

Rudd A, Bladin C, Carli P, Desilva D, Field TS, Jausch E, Kundenchuk P, Kurz M, Laerdal T, Ong MEH, Panagos P, Ranta A, Rutan C, Sayre M, Schoenau L, Shin SD, Waters D, Lippert F. Utstein Recommendations for Emergency Stroke Care. Int J Stroke 2020;15:555-564.

 

Rebchuk A, O’Neill ZR, Szefer E, Hill MD, Field TS. Health Utility Weighting of the Modified Rankin Scale: A Systematic Review and Meta-analysis. JAMA Network Open 2020;3:e203767.

 

Giustozzi M, Curcio A, Weijs B, Field TS, Sudikas S, Katholing A, Wallenhorst C, Weitz JI, Martinez C, Cohen AT. Variation in the association between antineoplastic therapies and venous thromboembolism in patients with active cancer. Thrombosis and Haemostasis 2020;120:847-56.

 

Botly L, Martin-Rhee M, Kasiban A, Swartz RH, Mulvagh SL, Lindsay P, Gioia C, Smith EE, Hill MD, Field TS, Krahn AD, Oudit GY, Zieroth S, Yip CYY. A contemporary perspective on the COVID-19 pandemic: Global impact and potential implications for cardiovascular and cerebrovascular disease in Canada. CJC Open 2020; 2:265-72.

 

Lu N, Smith JMC, Andrade JG, Flexman AM, Field TS. Stroke in adults with congenital heart disease – an illustrative teaching case. Stroke 2020;51:e148-50.

 

Ouyang Y, Karim E, Gustafson P, Field TS, Wong H.  Explaining the variation in the attained power of a stepped-wedge trial with unequal cluster sizes. BMC Medical Research Methodology 2020;20:166.

 

Gosselin-Lefevbre S, Salmeen AK, Byrne D, Shewchuk J, Field TS. Teaching neuroimages: An aTIPICal cause of neck pain. Neurology 2020; 95:e1112-3.

 

Zhou LW, Chew J, Field TS. Straight forward: Ischemic stroke with non-decussating corticospinal tracts causing ipsilateral weakness. Neurology 2020. epub ahead of print 9 Sep 2020. https://doi.org/10.1212/WNL.0000000000010804

 

Uy C, Gosselin-Lefebvre S, Book A, Field TS. Use of reperfusion therapy for acute ischemic stroke in pregnant and post-partum women: a Canadian Survey. Can J Neurol Sci 2020. epub ahead of print 22 Sep 2020. https://doi.org/10.1017/cjn.2020.207

 

Griesdale D, Sekhon M, Wood M, Cardim D, Brasher P, Sirounis D, Foster D, Krasnogoiova, Smielewski P, Scales D, Ainslie P, Menon D, Boyd F, Field TS, Dorian D. Near-infrared spectroscopy to assess cerebral autoregulation and optimal mean arterial pressure in patients with hypoxemic ischemic brain injury: A prospective multicenter pilot study. Crit Care Explorations 2020;2:e0217.

 

Zhou LW, Panenka WJ, Al-Momen G, Gicas KM, Thornton AE, Jones AA, Woodward M, Heran MKS, Vertinsky AT, Su W, Barr AM, MacEwan GW, Lang DJ, Rauscher A, Honer WG, Field TS. Cerebral small vessel disease, risk factors and cognition in tenants of precarious housing. Stroke 2020; 51:3271-8.

 

Shoamanesh A, Hart RG, Connolly S, Kasner S, Smith EE, Marti-Fabregas J, Liu YY, Uchiyama S, Mikulik R, Veltkamp R, O’Donnell M, Ntaios G, Muir K, Field TS, Santo G, Olavarria V, Mundl H, Lutsep H, Berkowitz S, Sharma M. Cerebral microbleeds and the effect of anticoagulation on outcomes in 3699 patients with embolic strokes of undetermined source: An exploratory analysis of the NAVIGATE ESUS trial. JAMA Neurol 2020; epub ahead of print 19 Oct 2020. https://doi.org/10.1001/jamaneurol.2020.3836

 

Ganesh A, Barber P, Black SE, Corbett D, Field TS, Frayne R, Hachinski V, Ismail Z, Mai LM, McCreary CR, Sahlas D, Sharma M, Swartz RH, Smith EE. Trial of remote ischemic pre-conditioning in vascular cognitive impairment: Protocol for a randomised controlled trial. BMJ Open 2020;13:e040466.

 

Rebchuk AD, Alimohammadi A, Yuan M, Cairncross M, Torres IJ, Silverberg ND, Field TS. Assessment of prorated scoring of an abbreviated protocol for the NIH Toolbox Cognition Battery. Journal of the International Neuropsychological Society 2020;26:1045-60.

 

Smith EE, Barber P, Field TS, Ganesh A, Hachinski V, Hogan DB, Lanctot K, Lindsay P, Sahlas D, Shara M, Swartz R, Ismail Z, Gauthier S, Black SE. CCCDTD5 guidelines for management of vascular cognitive impairment. Alz Dem Trans Res Clin Int 2020;6:e12056.

 

Yu AYX, Hill MD, Asdaghi N, Boulanger JM, Camden MC, Campbell BCV, Demchuk AM, Field TS, Goyal M, Krause M, Mandzia J, Menon BK, Mikulik R, Moreau F, Penn AM, Swartz RH, Coutts SB. Sex differences in diagnosis and diagnostic revision of suspected minor cerebral ischemic events. Neurology 2020; epub ahead of print 12 Nov 2020. https:///doi.org/10.1212/WNL.0000000000011212

 

Ohara T, Menon BK, Al-Ajlan F, Horn M, Najm M, Al-Sultan A, Puig J, Dowlatshahi D, Calleja A, Sohn SI, Ahn SH, Poppe A, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Letteri F, Dey S, Evans JM, Goyal M, Hill MD, Almekhalfi M, Demchuk AM. Thrombus migration and fragmentation after intravenous alteplase: the INTERRSeCT study. Stroke (In press)

 

Menon BK, Ospel JM, McTaggart RA, Nogueira RG, Demchuk AM, Poppe AY, Rempel J, Zerna C, Joshi M, Almekhlafi M, Field TS, Dowlatshahi D, van Adel B, Sauvageau E, Tarpley JW, Holmin S, Bang OY, Heck D, Jayaraman MV, Psychogios M, Tymianski M, Hill MD, Goyal M. Comparing perfusion and multiphase CT angiography for late window thrombectomy patient selection. J Neuroint Surg (In press)

 

Goyal M et al, On behalf of the HERMES Investigators. Endovascular therapy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomized trials. Lancet 2016;387:1723-31.

 

Saver JL et al, On behalf of the HERMES Investigators. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: A Meta-analysis. JAMA 2016;316:1279-89.

 

Johnson SC et al, On behalf of the POINT Investigators. Clopidogrel and Aspirin in acute ischemic stroke and high-risk TIA. 2018;379:215-25.

 

Hart RG et al, On behalf of the NAVIGATE-ESUS Investigators. Rivaroxaban for stroke prevention after Embolic Stroke of Undetermined Source. NEJM 2018;378:2191-2201.

 

Campbell BCV et al, On behalf of the HERMES Investigators. Effect of general anesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: A meta-analysis. Lancet Neurol 2018; 17:47-53.

 

San Roman L et al, On behalf of the HERMES Investigators. Imaging features and safety and efficacy of endovascular stroke treatment: A Meta-analysis of individual patient data. Lancet Neurol 2018;17:895-904.

 

Kasner SE et al, On behalf of the NAVIGATE-ESUS Investigators. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecfied subgroup analysis from the NAVIGATE-ESUS Trial. Lancet Neurol 2018;17:1053-60.

 

Campbell BCV et al, On behalf of the HERMES Investigators. Penumbral Imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: A meta-analysis. Lancet Neurol 2019;18:46-55.

 

Kong W, Jang H, Carenini G, Field TS. Machine Learning for Healthcare 2019. A Neural Model for Predicting Dementia from Language. (Machine Learning in Healthcare Conference 2019, Ann Arbor MI, research track proceedings) Proceedings of Machine Learning Research 2019; 106:270-286.

 

Barral O, Jang H, Newton-Mason S, Shajan S, Soroski T, Carenini G, Conati C, Field TS. Machine Learning for Healthcare 2020. Non-invasive classification of Alzheimer’s Disease using eye tracking and language. (Machine Learning in Healthcare Conference 2020, virtual event) Proceedings of Machine Learning Research 2020; 126:813-841.

 

Masrani V, Field TS, Murray G, Carenini G. Domain adaptation for detecting mild cognitive impairment. Proceedings of the Canadian AI Conference, Advances in Artificial Intelligence 2017; pp.248-259. (DOI 10.1007/978-3-319-57351-9_29)

 

Shoamanesh A, Catanese L, Romero JR, Lau H, Babikian VL, Benavente OR, Kase CS, Pikula A. High prevalence of cerebral microbleeds in inner city young stroke patients. J Stroke Cerebrovasc Dis. 2016 Jan 13 S1052-3057(15)00647-3.

 

Peralta CA, McClure LA, Scherzer R, Odden MC, White CL, Shlipak M, Benavente OR, Pergola P. Effect of Intensive Versus Usual Blood Pressure Control on Kidney Function Among Individuals With Prior Lacunar Stroke: A Post Hoc Analysis of the Secondary Prevention of Small Subcortical Strokes (SPS3) Randomized Trial. Circulation. 2016 Feb 9;133(6):584-91.

 

Boehme AK, McClure LA, Zhang Y, Luna JM, Del Brutto OH, Benavente OR, Elkind MS. Inflammatory Markers and Outcomes After Lacunar Stroke: Levels of Inflammatory Markers in Treatment of Stroke Study. Stroke. 2016 Mar;47(3):659-

 

Magvanjav O, McDonough CW, Gong Y, McClure LA, Talbert RL, Horenstein RB, Shuldiner AR, Benavente OR, Mitchell BD, Johnson JA; NINDS SiGN (Stroke Genetics Network). Pharmacogenetic Associations of β1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes). Stroke. 2017 May;48(5):1337-1343. PMID:28351962

 

Charidimou A, Turc G, Oppenheim C, Yan S, Scheitz JF, Erdur H, Klinger-Gratz PP, El-Koussy M, Takahashi W, Moriya Y, Wilson D, Kidwell CS, Saver JL, Sallem A, Moulin S, Edjlali-Goujon M, Thijs V, Fox Z, Shoamanesh A, Albers GW, Mattle HP, Benavente OR, Jäger HR, Ambler G, Aoki J, Baron JC, Kimura K, Kakuda W, Takizawa S, Jung S, Nolte CH, Lou M, Cordonnier C, Werring DJ. Microbleeds, Cerebral Hemorrhage, and Functional Outcome After Stroke Thrombolysis: Individual Patient Data Meta-Analysis. Stroke. 2017 Jul 18. PMID:28720659

 

Ikeme JC, Pergola PE, Scherzer R, Shlipak MG, Benavente OR, Peralta CA. Post Hoc Analysis of Randomized Clinical Trial for the Effect of Clopidogrel Added to Aspirin on Kidney Function.  Clin J Am Soc Nephrol. 2017 Jul 7;12(7):1040-1047. PMID: 28446537

 

Shoamanesh A, Pearce LA, Bazan C, Catanese L, McClure LA, Sharma M, Marti-Fabregas J, Anderson DC, Kase CS, Hart RG, Benavente OR; SPS3 Trial Investigators. Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, Mortality, and Treatment Interactions. Ann Neurol. 2017 Jul 6 [Epub ahead of print] PMID: 28681535

 

Malhotra R, Nguyen HA, Benavente OR, Mete M, Howard BV, Mant J, Odden MC, Peralta CA, Cheung AK, Nadkarni GN, Coleman RL, Holman RR, Zanchetti A, Peters R, Beckett N, Staessen JA, Ix JH. Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis. JAMA Intern Med. 2017 Oct 1;177(10):1498-1505. doi: 10.1001/jamainternmed.2017.4377. PMID: 28873137

 

Charidimou A, Shams S, Romero JR, Ding J, Veltkamp R, Horstmann S, Eiriksdottir G, van Buchem MA, Gudnason V, Himali JJ, Gurol ME, Viswanathan A, Imaizumi T, Vernooij MW, Seshadri S, Greenberg SM, Benavente OR, Launer LJ, Shoamanesh A; International META-MICROBLEEDS Initiative. Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1).  Int J Stroke. 2018 Jan 1:1747493017751931. doi: 10.1177/1747493017751931. [Epub ahead of print] PMID: 29338604

 

Elmariah S, Doros G, Benavente OR, Bhatt DL, Connolly SJ, Yusuf S, Steinhubl SR, Liu Y, Hsieh WH, Yeh RW, Mauri L. Impact of Clopidogrel Therapy on Mortality and Cancer in Patients With Cardiovascular and Cerebrovascular Disease: A Patient-Level Meta-Analysis. Circ Cardiovasc Interv. 2018 Jan;11(1):e005795. doi: 10.1161/.117.005795.PMID:29311290

 

Perera KS, Pearce LA, Sharma M, Benavente OR, Connolly SJ, Hart RG; ACTIVE A (Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events) Steering Committee and Investigators. Predictors of Mortality in Patients With Atrial Fibrillation (from the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events [ACTIVE A]). Am J Cardiol. 2018 Mar 1;121(5):584-589. doi: 10.1016/j.amjcard.2017.11.028. Epub 2017 Dec 11.PMID:29291887

 

Randhawa N, Wilson LK, Mann S, Sirrs S, Benavente OR. Clinical Reasoning: A complicated case of MELAS. Neurology. 2016 Oct 18;87(16):e189-e195.

 

McClure LA, Szychowski JM, Benavente OR, Hart RG, Coffey CS. A post hoc evaluation of a sample size re-estimation in the Secondary Prevention of Small Subcortical Strokes study. Clin Trials. 2016 Oct;13(5):537-44.

 

Khayambashi S, Fridhandler JD, Teal P, Barton JJ, Mann SK. Teaching Video NeuroImages: Thalamic infarct with pseudo-abducens and vertical gaze palsies and an unusual stroke mechanism. Neurology. 2016 Aug 9;87(6):e60. doi: 10.1212/WNL.0000000000002947. PMID: 27502969

 

Randhawa N, Squires JP, Heran MK, Mann SK. Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion. BMJ Case Rep. 2016 Oct 25;2016. pii: bcr2016012665. doi: 10.1136/bcr-2016-012665. PMID: 27797875

 

Randhawa N, Squires JP, Heran MKS, Mann SK. Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion. J Neurointerv Surg. 2017 Jun;9(6):e22. doi: 10.1136/neurintsurg-2016-012665.rep. Epub 2016 Oct 31.

 

Lee J, Inoue M, Mlynash M, Mann SK, Cereda CW, Ke M, Albers GW, Olivot JM. MR perfusion lesions after TIA or minor stroke are associated with new infarction at 7 days. Neurology. 2017 Jun 13;88(24):2254-2259. doi: 10.1212/WNL.0000000000004039. Epub 2017 May 12. PMID: 28500226.

 

Harris DR, Teal P, Turton M, Lahiffe B, Pulfrey S. Stroke Education in Canadian Emergency Medicine Residency Programs. Canadian Journal of Emergency Medicine. 2016 Jul;18(4):283-7.

 

Recurrent thunderclap headaches from reversible cerebral vasoconstriction syndrome associated with duloxetine, xylometazoline and rhinitis medicamentosa.

Pham H, Gosselin-Lefebvre S, Pourshahnazari P, Yip S.CMAJ. 2020 Nov 9;192(45):E1403-E1406. doi: 10.1503/cmaj.201234.

Canadian stroke best practice recommendations: Management of Spontaneous Intracerebral Hemorrhage, 7th Edition Update 2020.

Shoamanesh Co-Chair A, Patrice Lindsay M, Castellucci LA, Cayley A, Crowther M, de Wit K, English SW, Hoosein S, Huynh T, Kelly M, O’Kelly CJ, Teitelbaum J, Yip S, Dowlatshahi D, Smith EE, Foley N, Pikula A, Mountain A, Gubitz G, Gioia LC.Int J Stroke. 2020 Nov 11:1747493020968424. doi: 10.1177/1747493020968424. Online ahead of print

 

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.

Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators.N Engl J Med. 2018 Jul 19;379(3):215-225. doi: 10.1056/NEJMoa1800410. Epub 2018 May 16.

Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.

Saver JL, Carroll JD, Thaler DE, Smalling RW, MacDonald LA, Marks DS, Tirschwell DL; RESPECT Investigators.N Engl J Med. 2017 Sep 14;377(11):1022-1032. doi: 10.1056/NEJMoa1610057.

 

Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack.

Zhelev Z, Walker G, Henschke N, Fridhandler J, Yip S.Cochrane Database Syst Rev. 2019 Apr 9;4(4):CD011427. doi: 10.1002/14651858.CD011427.pub2.

 

Clinical predictors for favorable outcomes from endovascular recanalization in wake-up stroke.

Sung SM, Lee TH, Cho HJ, Cho GY, Jung DS, Lee JI, Ko JK, Yip S.

J Clin Neurosci. 2017 Jul;41:66-70. doi: 10.1016/j.jocn.2017.02.021.

 

Functional health and white matter hyperintensities as effect modifiers of blood pressure-lowering on cognitive function and vascular events in older Secondary Prevention of Small Subcortical Strokes trial participants.

Blum MR, Scherzer R, Ikeme JC, Benavente OR, McClure LA, Peralta CA, Odden MC.J Hypertens. 2020 Aug;38(8):1578-1585. doi: 10.1097/HJH.0000000000002440.

Higher Doses Improve Walking Recovery During Stroke Inpatient Rehabilitation.

Klassen TD, Dukelow SP, Bayley MT, Benavente O, Hill MD, Krassioukov A, Liu-Ambrose T, Pooyania S, Poulin MJ, Schneeberg A, Yao J, Eng JJ.Stroke. 2020 Sep;51(9):2639-2648. doi: 10.1161/STROKEAHA.120.029245. Epub 2020 Aug 19.

Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.

Keene KL, Hyacinth HI, Bis JC, Kittner SJ, Mitchell BD, Cheng YC, Pare G, Chong M, O’Donnell M, Meschia JF, Chen WM, Sale MM, Rich SS, Nalls MA, Zonderman AB, Evans MK, Wilson JG, Correa A, Markus HS, Traylor M, Lewis CM, Carty CL, Reiner A, Haessler J, Langefeld CD, Gottesman R, Mosley TH, Woo D, Yaffe K, Liu Y, Longstreth WT, Psaty BM, Kooperberg C, Lange LA, Sacco R, Rundek T, Lee JM, Cruchaga C, Furie KL, Arnett DK, Benavente OR, Grewal RP, Peddareddygari LR, Dichgans M, Malik R, Worrall BB, Fornage M; COMPASS, SiGN, and METASTROKE Consortia.Stroke. 2020 Aug;51(8):2454-2463. doi: 10.1161/STROKEAHA.120.029123. Epub 2020 Jul 22.

Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.

Keene KL, Hyacinth HI, Bis JC, Kittner SJ, Mitchell BD, Cheng YC, Pare G, Chong M, O’Donnell M, Meschia JF, Chen WM, Sale MM, Rich SS, Nalls MA, Zonderman AB, Evans MK, Wilson JG, Correa A, Markus HS, Traylor M, Lewis CM, Carty CL, Reiner A, Haessler J, Langefeld CD, Gottesman R, Mosley TH, Woo D, Yaffe K, Liu Y, Longstreth WT, Psaty BM, Kooperberg C, Lange LA, Sacco R, Rundek T, Lee JM, Cruchaga C, Furie KL, Arnett DK, Benavente OR, Grewal RP, Peddareddygari LR, Dichgans M, Malik R, Worrall BB, Fornage M; COMPASS, SiGN, and METASTROKE Consortia.Stroke. 2020 Aug;51(8):2454-2463. doi: 10.1161/STROKEAHA.120.029123. Epub 2020 Jul 22.

Pharmacogenetic Associations of β1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes).

Magvanjav O, McDonough CW, Gong Y, McClure LA, Talbert RL, Horenstein RB, Shuldiner AR, Benavente OR, Mitchell BD, Johnson JA; NINDS SiGN (Stroke Genetics Network).Stroke. 2017 May;48(5):1337-1343. doi: 10.1161/STROKEAHA.116.015936.

Cerebral White Matter Hyperintensities, Kidney Function Decline, and Recurrent Stroke After Intensive Blood Pressure Lowering: Results From the Secondary Prevention of Small Subcortical Strokes ( SPS 3) Trial.

Ikeme JC, Pergola PE, Scherzer R, Shlipak MG, Catanese L, McClure LA, Benavente OR, Peralta CA.J Am Heart Assoc. 2019 Feb 5;8(3):e010091.

Impact of Clopidogrel Therapy on Mortality and Cancer in Patients With Cardiovascular and Cerebrovascular Disease: A Patient-Level Meta-Analysis.

Elmariah S, Doros G, Benavente OR, Bhatt DL, Connolly SJ, Yusuf S, Steinhubl SR, Liu Y, Hsieh WH, Yeh RW, Mauri L.Circ Cardiovasc Interv. 2018 Jan;11(1):e005795. doi: 10.1161/CIRCINTERVENTIONS.117.005795.

 

The uncertain role for phosphodiesterase inhibitors in stroke prevention.

Hill MD, Benavente OR.Lancet Neurol. 2019 Jun;18(6):515-517. doi: 10.1016/S1474-4422(19)30165-6.

 

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O’Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM; Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC).Neurology. 2017 Oct 24;89(17):1829-1839. doi: 10.1212/WNL.0000000000004560.

Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1).

Charidimou A, Shams S, Romero JR, Ding J, Veltkamp R, Horstmann S, Eiriksdottir G, van Buchem MA, Gudnason V, Himali JJ, Gurol ME, Viswanathan A, Imaizumi T, Vernooij MW, Seshadri S, Greenberg SM, Benavente OR, Launer LJ, Shoamanesh A; International META-MICROBLEEDS Initiative.Int J Stroke. 2018 Jul;13(5):454-468.

Determining optimal poststroke exercise: Study protocol for a randomized controlled trial investigating therapeutic intensity and dose on functional recovery during stroke inpatient rehabilitation.

Klassen TD, Dukelow SP, Bayley MT, Benavente O, Hill MD, Krassioukov A, Liu-Ambrose T, Pooyania S, Poulin MJ, Yao J, Eng JJ.Int J Stroke. 2019 Jan;14(1):80-86.

 

 

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS; MEGASTROKE project of the International Stroke Genetics Consortium.Neurology. 2019 Feb 26;92(9):e944-e950.

Genome-wide association analysis of common genetic variants of resistant hypertension.

El Rouby N, McDonough CW, Gong Y, McClure LA, Mitchell BD, Horenstein RB, Talbert RL, Crawford DC; eMERGE network, Gitzendanner MA, Takahashi A, Tanaka T, Kubo M, Pepine CJ, Cooper-DeHoff RM, Benavente OR, Shuldiner AR, Johnson JA.Pharmacogenomics J. 2019 Jun;19(3):295-304. doi: 10.1038/s41397-018-0049-x.
A telehealth intervention to promote healthy lifestyles after stroke: The Stroke Coach protocol.

Sakakibara BM, Lear SA, Barr SI, Benavente O, Goldsmith CH, Silverberg ND, Yao J, Eng JJ.Int J Stroke. 2018 Feb;13(2):217-222. doi: 10.1177/1747493017729266.
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5.

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Neurology. 2019 Jan 16;92(5):e486-503.

 

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3.

 

Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association.

Gorelick PB, Furie KL, Iadecola C, Smith EE, Waddy SP, Lloyd-Jones DM, Bae HJ, Bauman MA, Dichgans M, Duncan PW, Girgus M, Howard VJ, Lazar RM, Seshadri S, Testai FD, van Gaal S, Yaffe K, Wasiak H, Zerna C; American Heart Association/American Stroke Association.Stroke. 2017 Oct;48(10):e284-e303.

Clinical and Technological Approaches to the Prehospital Diagnosis of Large Vessel Occlusion.

van Gaal S, Demchuk A.Stroke. 2018 Apr;49(4):1036-1043. doi: 10.1161/STROKEAHA.117.017947.

Cytomegalovirus encephalitis radiographically mimicking lateral medullary stroke.

Li D, van Gaal S.Neurol Clin Pract. 2018 Dec;8(6):e37-e39.

Physician engagement: the Vancouver Medical Staff Association engagement charter.

Rabkin SW, Dahl M, Patterson R, Mallek N, Straatman L, Pinfold A, Charles MK, van Gaal S, Wong S, Vaghadia H.Clin Med (Lond). 2019 Jul;19(4):278-281.

Physician engagement: the Vancouver Medical Staff Association engagement charter.

Rabkin SW, Dahl M, Patterson R, Mallek N, Straatman L, Pinfold A, Charles MK, van Gaal S, Wong S, Vaghadia H.Clin Med (Lond). 2019 Jul;19(4):278-281.

Pulmonary Function Testing in Elderly Patients Treated for a Myasthenia Gravis Exacerbation.

van Gaal SC, English SW, Bourque PRJ, Zwicker JC.Neurohospitalist. 2019 Apr;9(2):79-84.

Early Secondary Prevention in Transient Ischemic Attack (TIA) and Minor Stroke.

Tse D, Hill MD, Coutts SB.Curr Neurol Neurosci Rep. 2019 May 14;19(6):34.
Ulnar neuropathy with abnormal non-localizing electrophysiology: Clinical, electrophysiological and ultrasound findings.

Pelosi L, Tse DMY, Mulroy E, Chancellor AM, Boland MR.Clin Neurophysiol. 2018 Oct;129(10):2155-2161. doi: 10.1016/j.clinph.2018.07.020. Epub 2018 Aug 12.